1. Hexarelin Helps in Muscle Preservation

Hexarelin stimulates the release of growth hormone, which in turn promotes protein synthesis, reduces muscle breakdown, and causes cells to differentiate and proliferate. Literature shows that hexarelin can preserve muscle mass.

In one study, researchers induced cachexia (muscle loss) in rats using cisplatin. The rats were divided into two groups: one received a placebo (the control group), while the other group was treated with hexarelin. The results indicated that the control group experienced mitochondrial dysfunction and muscle atrophy. On the other hand, the treatment group showed resistance to muscle loss and maintained muscle strength. Furthermore, it was suggested that the improved mitochondrial function and reduced inflammatory processes contributed to this effect of hexarelin .

2. Hexarelin in Weight Loss

Hexarelin has been shown to improve fat metabolism via its action at the CD36 receptor. A study was conducted to check the impact of hexarelin on body weight in nonobese insulin-resistant MKR mice and its corresponding wild-type FVB mice. The subjects were randomized to receive peritoneal injection of hexarelin or placebo two times a day for 12 days, Researchers found that hexarelin decreased liver and plasma triglyceride levels. Further, it also improved glucose levels and insulin tolerance. Additionally, the study found that hexarelin achieved this effect by improving lipid metabolism and increasing the adipocyte differentiation of white adipose tissues. These findings indicate that hexarelin might prove to be effective in treating lipid disorders.

3. Hexarelin helps in Cardioprotection

Scientific literature shows that hexarelin has the potential to prevent cardiac remodeling and myocardial infarction. One study examined the cardioprotective effect of hexarelin in spontaneously hypertensive rats. Subjects aged 16 weeks were treated with either hexarelin alone or the combination of hexarelin and GHS-R antagonist for 5 weeks. The results found that hexarelin reduced cardiac fibrosis through decreasing myocardial collagen deposition and myocardial hydroxyproline content. It also suppressed the expression of collagen I and III and accelerated the degradation of collagen through the regulation of metalloproteinase II. Additionally, it relieved left ventricular hypertrophy, reduced high blood pressure, and improved left ventricular function.

Hexarelin Peptide and Composition

One study⁽¹³⁾ aimed to determine the possible fluctuation of sex-based weight composition with the growth hormone-releasing potential of Hexarelin. This study evaluated the impact of Hexarelin exposure, and upon analyzing the test samples, researchers suggested that the stimulus of Hexarelin and the consequent peak growth hormone release appeared to be negatively correlated to fat mass. Increased fat mass may lead to a reduction in GH release following Hexarelin exposure. Gender reportedly exhibited no significant impact on GH release.

Hexarelin Peptide and Muscle Tissue

Preliminary experiments suggest that Hexarelin may have sparing effects on muscle tissue in research models exposed to catabolic conditions. Several such experiments have reported an apparent reduction in muscle mass loss and muscle strength loss, potentially due to the action of Hexarelin. For example, one of the studies suggested that a group of research models exposed to catabolic agents lost 12% muscle mass. In comparison, the addition of Hexarelin may have lowered that loss to 7%.⁽¹⁴⁾ A similar experiment also commented that the peptide may have attenuated the reduction in strength levels associated with exposure to catabolic agents.